It's been six months since the deadpool,  Kate and Peter, but that moment of peace is about to end. Senior year is starting and the teenagers are met with genetically modified supernatural creatures, supernatural doctors, and an old friend coming back and ruining everything.

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Zendaya
as
Amara Hale

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Holland Roden
as
Lydia Martin

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Tyler Posey
as
Scott McCall

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Dylan O'Brien
as
Stiles Stilinski

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Arden Cho
as
Kira Yukimura

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Shelley Hennig
as
Malia Tate

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Dylan Sprayberry
as
Liam Dunbar

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Lesley-Ann Brandt
as
Makena Adisa

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Khylin Rhambo
as
Mason Hewitt

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Cody Christian
as
Theo Raeken

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Victoria Moroles
as
Hayden Romero

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Seth Gilliam as Alan Deaton
Linden Ashby as Noah Stilinski
Melissa Ponzio as Melissa McCall
Ryan Kelly as Jordan Parrish
Tamlyn Tomita as Noshiko Yukimura
Tom T. Choi as Ken Yukimura
Cody Saintgnue as Brett Talbot
Michael Johnston as Corey Bryant
Kelsey Chow as Tracy Stewart