Mike Tyson made his videogame debut in Mike Tyson's Punch Out! on the Nintendo Entertainment System as the final opponent of the game, whom Little Mac faces in the Dream Fight at the end.

Classification: Human, the champ

Powers and Abilities: Peak Human physical characteristics, skilled boxer

Attack Potency: At least Street level(Able to knock Little Mac down in one hit. Should be comparable to real life professional boxers, and is also superior to every other boxer in the game)

Speed: Peak Human (Should be comparable to real life boxers)

Lifting Strength: Peak Human

Striking Strength: At least Street Class(Superior to Little Mac and every other boxer in the game)

Durability: At least Street level (Took dozen of hits from Little Mac)

Stamina: At least Above Average(Although Tyson's attacks gets weaker after the first round, he's still able to get up from getting knocked down and fights for three rounds despite being constantly pelted with punches from Little Mac)

Range: Standard melee range

Standard Equipment: Boxing Gloves and boots

Intelligence: Average; skilled boxer prodigy

Weakness: Mike Tyson's blows weaken as the fight continues.

Standard Tactics: Mike Tyson opens the fight with uppercuts and will continuously do them for 90 seconds, after that he mixes uppercuts, jabs, hooks, and blocks in an extreme offensive and defensive front.