"Provenza" was released on April 21, 2022, as the album's lead single. The song was serviced to contemporary rhythmic radio in the United States on June 7, 2022. The song was a commercial success, becoming the highest peaking full-Spanish song by a female soloist on the US Billboard Hot 100 chart at number 25. The song also reached the top spot US Billboard Hot Latin Songs. It was nominated for Record of the Year and Song of the Year at the 23rd Annual Latin Grammy Awards.

"Gatúbela" with Puerto Rican rapper Maldy was released on August 25, 2022, as the album's second single. The song was described as "an infectious old-school reggaeton laced with intense perreo beats". It reached the top 40 of the US Billboard Hot 100 chart, at number 37. It also peaked inside the top 5 at number 4 on the US Billboard Hot Latin Songs.

"Cairo" with long-time producer Ovy on the Drums was released on November 13, 2022, as the third single from the album. The song peaked inside the top 15 of the US Billboard Hot Latin Songs. It was awarded triple platinum certification in the United States.

"X Si Volvemos" with American singer Romeo Santos was released on February 2, 2023, as the fourth single from the album. It reached the top 60 of the US Billboard Hot 100 chart, at number 56. It also peaked at number 5 on the US Billboard Hot Latin Songs.

"TQG with Colombian singer Shakira was released alongside the album's release on February 24, 2023. It became Karol G's first number-one single on the Billboard Global 200. It also debuted at number seven on the US Billboard Hot 100, becoming Karol G's first top-ten and highest-charting single.

"Mientras Me Curo del Cora" was released as the sixth single on March 7, 2023. It reached the top 70 of the US Billboard Hot 100 chart, at number 68 and peaked at number 8 on the US Billboard Hot Latin Songs.

"Amargura" was released as the seventh and final single on May 19, 2023. It entered the US Billboard Hot 100 chart, and peaked at number 14 on the US Billboard Hot Latin Songs.