Dean was in a dim hallway, grimly turning towards a door and pulled out a gun. He slid out the clip, tapped it on the gun, then replaced it. Inside the room, there was a Crater Lake poster on the wall. Below it, a young blond man, Duane, was tied to a chair. Nearby, were a young woman, Pam, a middle-aged woman, Dr. Lee, and a tough-looking black man, Mark. Duane looked up as Dean opened the door and entered, raising the gun.

Duane began babbling. "No, no, no, no, no, you're not gonna... no, I swear! It's not in me!"

"Oh, God," Pam said. "We're all gonna die."

"Maybe he's tellin' the truth," Mark guessed.

Dean advanced and cocked the gun. "He's not him, not anymore."

"No, stop it!" Duane cried. "Stop it! Ask her, ask the doctor! It's not in me!"

"I just... I can't tell," Dr. Lee admitted.

"No, please, don't. Don't. I swear I-"

"I got no choice," Dean said.

Duane started sobbing. "I swear, it's not in me, it's not in me! Don't, don't. Please!"

Dean fired twice.

MOTEL ROOM

Sam was lying on the floor beside a motel bed and coming out of his vision. Adeline was shaking his shoulder. The door opened and Dean entered, chewing on jerky and carrying a six-pack of beer. Sam sat up, panting.

"Sam?" Dean called.

"No..." Sam said.

The trio got into the Impala. Adeline buckled her sleeping daughter in. Dean was driving, Adeline and Eva were in back, and Sam was navigating with a GPS device which spoke directions.

"Continue on O-R Two-Two-Four West."

"There are only two towns in the US named Rivergrove," Sam told his brother and friend.

"How come you're so sure it's the one in Oregon?" Dean asked.

Sam had a flashback -- the Oregon poster on the wall. "There was a picture. Crater Lake."

"Okay, what else?"

"I saw a dark room, some people, and a guy tied to a chair."

"And I ventilated him?"

"Yeah. You thought there was something inside him."

"What, a demon? Was he possessed?" Adeline questioned.

"I don't know."

"Well, all your weirdo visions are always tied to the Yellow-Eyed Demon somehow... so was there any back smoke? Did we try to exorcise it?" Dean wondered.

"No. Nothing, you just plugged him, that's it."

"Well, I'm sure I had a good reason."

"I sure hope so."

"What does that mean?" There was a silent beat. "I mean, I'm not gonna waste an innocent man." Sam raised his eyebrows. "I wouldn't!"

"I never said you would!"

"Fine!"

"Fine! Look, we don't know what it is. But whatever it is, that guy in the chair's a part of it. So let's find him, and see what's what."

"Fine."

"Fine."

Adeline sighed. "Thank goodness. Don't wake Eva, boys."

RIVERGROVE STREET

The four pulled into town past a large billboard advertising Crater Lake. They pulled up in front of a wooden shop. Out front, a man in a short-sleeved blue shirt and a multi-pocket brown vest, Mark was cleaning a rifle. Sam, Dean and Adeline, holding her daughter, got out and approached him.

"Morning," Dean greeted.

"Good morning," Mark replied. "Can I help you?"

"Yeah." Dean pulled out a badge. "Uh, Billy Gibbons, Frank Beard, Dusty Hill. U.S. Marshals."

"What's this about?"

"We're looking for someone," Adeline told him.

"A young man, early 20s," Sam added, flashing to his vision. "He'd have a, a thin scar right below his hairline."

"What'd he do?" Mark asked.

"Well, nothing. We're actually looking or someone else, but we think this young man could help us."

"Yeah, he's not in any kind of trouble or anything; well, not yet," Dean said, glancing down at Mark's left arm, which showed a distinctive tattoo. "I think maybe you know who he is... Master Sergeant." He smiled. "My dad was in the Corps, he was a Corporal."

"What company?"

"Echo-2-1."

"So can you help us?" Sam questioned.

Mark hesitated. "Duane Tanner's got a scar like that. But I know him. Good kid, keeps his nose clean."

"Oh, I'm sure he does," Dean replied. "Um. You know where he lives?"

"With his family, up Aspen Way."

"Thank you."

They left. Mark frowned as he watched them go. Across the street, Sam bumped into a telephone pole and glanced at it in passing. He stopped, seeing a single word carved into the wood: CROATOAN.

They approached the pole and Sam pointed at the word with a significant look. "Hey."

"Croatoan?" Dean and Adeline repeated.

"Yeah." Dean looked at him blankly. "Roanoke? Lost colony? Ring a bell? Dean, did you pay any attention in history class?"

"Yeah!" Dean cried. "Shot 'heard round the world, How bills become laws..."

Adeline raised a brow. "That's not school, that's Schoolhouse Rock."

"Whatever."

She continued. "Roanoke was one of the first English colonies in America, late 1500s."

"Oh, yeah, yeah, I do remember that. The only thing they left behind was a single word carved in a tree. Croatoan."

"Yeah," Sam said. "And I mean, there were theories -- Indian raid, disease, but nobody knows what really happened. They were all just gone. I mean, wiped out overnight."

"You don't think that's what's going on here, I mean..."

"Whatever I saw in my head, it sure wasn't good. But what do you two think could do that?"

"Well, I mean, like I said, all of your weirdo visions are always connected to the Yellow-Eyed Demon somehow, so..."

"We should get help," Adeline suggested. "Bobby, uh, Ellen maybe?"

"Yeah, that's a good idea." Dean pulled out his phone and frowned at it. "I don't have a signal."

Sam and Adeline did the same and shook their heads. "I don't either."

They walked to a pay phone and Dean picked it up. He heard the out of service beeping and clicked the receiver several times.

"Line's dead," Dean said, hanging up. "I'll tell you one thing. If I was gonna massacre a town, that'd be my first step."

They drove to the Tanner house, in the middle of nowhere. Sam, Dean and Adeline approached the front. Eva was left in the car. By the door was a small tacky plaque that read, BORN TO FISH; FORCED TO WORK. Sam knocked on the door and a teenaged boy with dark spiked hair, Jake, opened it.

"Yeah?" Jake asked.

Dean flashed his badge. "We're looking for Duane Tanner, he lives here, right?"

"Yeah, he's my brother."

"Can we talk to him?"

"Oh, he's not here right now."

"Do you know where he is?"

"Yeah, he went on a fishing trip up by Roslyn Lake."

"Your parents home?" Sam questioned.

"Yeah, they're inside."

"Jake? Who is it?" Mr. Tanner asked from inside.

Dean, as Mr. Tanner appeared, said, "Hi, U.S. Marshals, sir, we're looking for your son Duane."

"Wh-why? He's not in trouble, is he?"

"No, no, no, no. We just need to ask him a couple of routine questions, that's all."

"When's he due back from his fishing trip?" Adeline questioned.

"I'm not sure."

"Well, maybe your wife knows," Sam said.

"No, I don't know, she's not here right now."

"Your son said she was," Dean stated.

Jake frowned. "Did I?"

"She's getting groceries," Mr. Tanner informed. "So, when Duane gets back, there's a number where he can get a hold of you?"

"Oh no, we'll just check in with you later."

They turned and walked down the steps as the Tanners shut the door behind them.

Dean glanced between his brother and friend. "That was kind of creepy, right? A little too Stepford?"

"Big time," Sam and Adeline agreed.

They looked furtively about and snuck around the back of the house and crouched below a window.

Inside the Tanner house, Beverly Tanner was tied to a chair and gagged; Jake came around behind her, hands on her shoulders.

"It's okay, Mom. It's not gonna hurt," Jake reassured.

Mr. Tanner came out of the next room with a kitchen knife. Jake stood in front of his mother and casually rolled up one sleeve; his father cut into his arm and let the blood drip onto a wound in Beverly's shoulder.

Outside, Sam, Dean and Adeline armed themselves and kicked down the back door. As they rushed in, handguns raised, Mr. Tanner rushed at them with a knife and Dean shot him thrice in the chest. Jake jumped out the window, shattering glass, and darted off into the woods. Sam aimed at him through the window, but hesitated, giving him time to get away.

Adeline made her way towards Beverly and untied her.

The boys loaded her into the back and Adeline slid in.

As soon as they drove up, Sam helped her out and led her to the door. Dean opened the trunk, Adeline joined him, and they looked around furtively.

CLINIC

Sam led Beverly inside. The clinic was quiet, dim, and empty.

"Hello?" Sam called. "Hello? We need a doctor here!"

The young woman from the vision, Pam, rushed out, concerned.

"Mrs. Tanner, what happened?" Pam asked.

"She's been attacked," Sam explained.

"Dr. Lee?"

Dr. Lee rushed in. "Bring her in."

"Okay," Sam said.

Pam led Sam and Beverly into a back room and Dr. Lee followed. Dean and Adeline, holding Eva, entered, and Dean was carrying the canvas-covered body of Mr. Tanner hoisted over his shoulders.

"Is that-" Dr. Lee began.

"Mr. Tanner," Dean and Adeline confirmed.

"Was he attacked too?"

"Uh... no, actually, he did the attacking and then he got himself shot," Dean explained.

"Shot?"

"Yeah," Adeline answered.

"And who are you three?"

"U.S. Marshals," Dean told her. "Pardon the kid. I'd show you my badge, but uh..."

"Oh. Sorry. Bring him back here."

Adeline held up her badge. "Here."

Dr. Lee glanced at the badge and nodded. "Thanks."

LAB

Beverly was seated on a stool with her shirt off. Dr. Lee sat across from her, treating the wound on her left shoulder. Eva had been sat in a chair with some board books and toys.

"Wait, you said Jake helped him?" Dr. Lee asked. "Your son Jake?"

Beverly nodded. "They beat me. Tied me up."

"I don't believe it," Pam said.

"Pam," Dr. Lee called. "Beverly... do you have any idea why they would act this way? Any history of chemical dependency?"

"No, of course not," Beverly replied. "I don't know why. One minute they were my husband and my son. And the next, they had the devil in them."

Sam, Dean and Adeline were listening and they shared a look at her last words.

"We gotta talk," Dean said, ushering his brother and friend from the lab. "Those guys were whacked out of their grounds."

"What do you think?" Sam asked. "Multiple demons, mass possessions?"

"If it is possession, there could be more. I mean, God knows how many, it could be like a friggin' Shriner convention."

"Great."

"Of course, that's one way to wipe out a town, you take it from the inside," Adeline pointed out.

"I don't know, man, Adeline. We didn't see any of the demon smoke with Mr. Tanner, or any of the other usual signs."

"Well, whatever," Dean replied. "Something turned him into a monster. And you know if you woulda taken out the other one, there'd be less to worry about."

"I'm sorry, all right? I hesitated, Dean, it was a kid!"

"No, it was an "it". Not the best time for a bleeding heart, Sam."

Dr. Lee stalked out of the lab, her heels clicking loudly on the floor.

"How's the patient?" Sam questioned.

"Terrible!" Dr. Lee cried. "What the hell happened out there?"

"We don't know," Dean said.

"Yeah? Well, you just killed my next door neighbor."

"We didn't have a choice."

"Maybe so, but we need the county sheriff. I need the coroner..."

"Phones are down," Sam informed.

"I know, I tried. Tell me you have a police radio in the car?"

"Yeah we do. But it crapped out just like everything else."

"I don't understand what is happening."

"How far is it to the next town?" Adeline asked.

"It's about forty miles down to Sidewinder."

Dean said, "All right, I'm gonna go down there with my partner, see if we can find some help." He clipped Sam on the shoulder. "Our other partner'll stick around, keep you guys safe."

"Safe from what?"

"We'll get back to you on that."

Adeline looked at Sam. "Keep Eva safe."

BLACKTOP

Dean pulled up behind a wrecked car with Oregon plates that read WTF 4C7. He stopped to investigate, carrying a gun. Saoirse armed herself with her sword as she followed him around. The windows on the car were smashed and blood covered the seats. On the ground by the driver's side was a large bloody knife. He picked it up.

CLINIC

Sam was leaning against a counter, staring at the body of Mr. Tanner. He began pacing. Dr. Lee was nearby, looking at something in a microscope.

"Huh," Dr. Lee noted.

"What?" Sam asked.

"His lymphocyte percentage is pretty high. His body was fighting off a viral infection."

"Really? What kind of virus?"

"Can't say for sure."

"Do you think an infection could have made him act like that?"

"None that I've ever heard of. I mean, some can cause dementia, but not that kind of violence. And besides, I've never heard of one that did this to the blood."

"Did what?"

"There's this... weird residue. If I didn't know better, I'd say it was sulfur."

"Sulfur."

BLACKTOP

Dean and Adeline drove along the bridge, which was blocked by a roadblock consisting of several cars and a half-dozen locals with guns. One was Jake. He stopped the car and frowned. Something banged down on the roof of the car and they jumped; a man leaned over.

"Oh-ho-ho. Hey," Dean greeted.

"Sorry. Road's closed," a man told them.

"Yeah, I can see that. What's up?"

"Quarantine."

"Quarantine?" Adeline repeated. "What is it?"

"Don't know. Something going around out there."

"Uh-huh. Who told you that?" Dean questioned.

"County Sheriff."

"Is he here?"

"No. He called. Say, why don't you two get out of the car and we'll talk a little?"

Dean laughed nervously. "Well, you are a handsome devil, but I don't swing that way, sorry. And there's no way I'm lettin' you go for her."

"I'd appreciate it if you two got out of the car, just for a quick minute."

"Yeah, I'll bet you would."

Dean put the car into a quick reverse. The man grabbed his collar and was dragged along. The men at the roadblock began firing, and Dean swung the car around, shaking the man off and zoomed away.

"You good?" Adeline asked.

"Yeah. Are you?"

"Yeah."

CLINIC

Sam was staring intently at Beverly, still huddled on the stool in the lab.

"I don't understand," Beverly said. "Are you saying my husband and Jake had a disease?"

"That's what we're trying to figure out," Dr. Lee replied. "Now, during the attack, do you remember... did you have any direct contact with their blood?"

"Oh, my God. You don't think I've got this virus, do you?"

"Beverly, I don't know what to think. But with your permission, we'll take a blood sample."

Beverly nodded and laid her hand gently on Dr. Lee's. Suddenly, she grabbed Dr. Lee's wrist and yelled in rage, lashing out with her other hand. Sam advanced on her and she tossed him against a glass cabinet, which shattered. She picked up a scalpel as he took a fire extinguisher from the wall. She advanced on him, still yelling, and he knocked her out.

Eva, hearing the noises, went to investigate and Sam grabbed her before she could come any closer.

TOWN ROAD

Dean and Adeline were driving back into town. Mark stepped into their path brandishing a rifle, and he stopped the car.

"Hands where I can see 'em!" Mark ordered.

"Okay!" Dean and Adeline agreed.

"Get out of the car! Out of the car!"

Dean opened the car door and got out slowly, shielding Adeline's body as she got out. "All right, easy there, big guy."

As he stood, still guarding Adeline's body, he pulled out a handgun and pointed it at Mark. "All right, put it down!"

"Lower it now!" Mark yelled.

"Put it down!"

"Are you one of 'em? Is she?"

"No! Are you?"

"No!" Adeline yelled.

"No!" Mark answered.

"You could be lying!" Dean told him.

"So could you two!"

"All right! All right. We could do this all day, all right? Let's just, uh, let's take it easy before we kill each other."

Mark relaxed slightly. "What's going on with everybody."

"We don't know."

"My neighbor... Mr. Rogers, he-"

"You've got a neighbor named Mr. Rogers?"

"Not anymore." Dean and Adeline shook their heads. "He came at me with a hatchet. I put hm down. He's not the only one, I mean, it's happening to everyone."

"We're heading over to the doc's place, there's still some people left," Adeline told Mark.

"No, no way. I'm getting the hell out."

"There's no way out, they got the bridge covered, come on."

"I don't believe you."

"Fine, stay here, be my guest," Dean said.

Mark hesitated, then changed his mind. He pulled out his handgun and grabbed another and kept it pointed towards Dean and Adeline as he got into the passenger's side. Dean still had his gun up as well.

"Well, this ought to be a relaxing drive," Dean muttered.

CLINIC

Dr. Lee was looking through the microscope again as Pam huddled against the far wall.

"What if we all have it? What if we all go crazy?" Pam asked.

"You've got to stay calm," Dr. Lee told her. "All we can do it wait. The Marshal's bringing help."

"I can't, I... I've got to go."

"Pam!"

"No, you don't understand. My boyfriend's out there, I gotta make sure he's okay." She hurried out of the lab.

Sam, still holding Eva, followed Pam to the hallway. "All right, wait, wait. Please. Look, I know you're upset, all right? But it's safer if you stay here for now. Help is coming." The Impala pulled up outside. "There they are."

"Sammy? Open up!" Dean and Adeline called.

Sam opened the door to let in Dean, Mark and Adeline, all who were still armed.

"Did you guys, uh, get to a phone?" Sam asked.

"Road block," Dean answered, turning to Mark. "We're gonna have a word. Doc's inside."

"What's going on out there, Dean, Adeline?"

"Man, we don't know, I feel like Chuck Heston in the Omega Man, I mean, Sarge is the only sane person we could find. What are we dealing with, do you know?"

"Yeah. Doc thinks it's a virus."

"Okay, great," Adeline said, taking her daughter. "What do you think?"

"I think she's right."

"Really?" Dean and Adeline questioned.

"Yeah. And I think the infected are trying to infect others with blood-to-blood contact. Oh, but it gets better. The uh, the virus? Leaves traces of sulfur in the blood."

"A demonic virus?"

"Yeah, more like a demonic germ warfare. At least it explains why I've been having visions."

"It's like a Biblical plague," Dean noted.

"Yeah. You don't know how right you are, Dean. I've been poring through Dad's journal, found something about the Roanoke colony."

"And?" Saoirse pressed.

"Dad always had a theory about Croatoan. He thought it was the demon's name. Sometimes known as a Deva or sometimes Reesha. A demon of plague and pestilence."

"Well, that's just terrific. Why here, why now?"

"I have no idea. But Dean, Adeline, who knows how far this thing can spread? We gotta get out of here, we gotta warn people."

Mark called, "They've got one! In here!"

Dean and Adeline entered the next room as Dean asked, "What do you