After the intense events of The Amazing Spider-Man 2 (2014), Peter fights his greatest foe yet, guilt for the death of his girlfriend, Gwen Stacy. Peter gets a job at Horizon Labs working with Doctor Otto Octavius on an experimental treatment to people with amputated limbs. The experimental Symbiote escapes the lab during a fight, causing Otto and Peter to be both fired from their jobs. Otto is driven mad by his search for the symbiote, but little does he know that Peter has already found it..
