Once Hatice discovers Ibrahim's adultery, she immediately sentences Nigar to prison. She then confronts Ibrahim, and assures him she knows Nigar is pregnant with his child, because Nasuh confessed everything after Hatice confronted him. Hatice tells Ibrahim she will divorce from him and expulses Ibrahim from their palace.

The next morning Hatice arrives at Topkapi and accuses Hurrem of trying to ruin her life, but Hurrem states she had nothing to do with it, and that she did not know anything before Gulsah told her.

Hatice then meets with Suleyman and notifies him of Ibrahim's affair with Nigar. Suleyman then bestows Hatice the authority to make the decisions referring to that, and disowns Ibrahim himself.

Gulfem talks with Hatice and convinces her not to divorce from Ibrahim, only because it would please Hurrem.

Hurrem is furious once she is informed Hatice and Ibrahim will not divorce, and quickly begins to devise another plan.

Ibrahim goes to war with Persia and Hatice secludes herself in depression.

Nigar gives birth to a girl, but Hatice hid it from Nigar, leaving her to think Hatice killed it.

Years go by, and Ibrahim returns from his campaign, to find that though Hatice did not divorce from him, she is still shunning his affection. He tries to rescue his relation to her, but she refuses to hear him.

Hurrem is upset about Ibrahim's return, but is happy after being told that Hatice will not speak with him.

Although, one night, he finally managed to rescue his relationship with her, and they reconcile.

Hatice and Ibrahim both plot against Hurrem.

Hisir Reis finds a girl amongst a ship wreck, and she is sold to Topkapi.

Hatice suffers a stroke in the Topkapi after seeing Hurrem mock her from the terrace. The girl heals her. Gulfem witnesses this and asks the girl's name. Her name is Firuze.

Once Hatice recovers, she thanks Firuze for saving her life. Then Suleyman arrives, and Firuze has a strange vision of him.

The rumor of Firuze's healing talent spreads through the harem.

Mihrimah Sultan is in love with Yahya, Şehzade Mustafa's closest friend. Mustafa sets out to Manisa where he serves as a Sancak Beyi.

Süleyman want to go on a hunting trip but his daughter doesn't want to come because Firuze is coming and not her mother, Hürrem. Hürrem threatens to kill Firuze.

Few years later Hürrem discovers Qadar, the secret daughter of Nigar and İbrahim. Hürrem notifies İbrahim. Hürrem gives the child to İbrahim.

Fatma Hatun gives birth to a boy. Süleyman goes to Manisa to see Mustafa's son and names the boy Süleyman as his name. Hürrem, Şehzade Mehmed and Mihrimah also go with Süleyman. Seeing Süleyman's closeness to Mehmed, Mustafa starts feeling threatened by Mehmed. On a secret meeting with İbrahim, the Grand Vizier manages to persuade the prince to send Helena away.

While trying to kill Firuze on Hürrem's command, Rüstem finds out that the tattoo on her neck is connected to the Safavid dynasty . He notifies Hürrem, who informs Süleyman and the Sultan decides to send her away.

Hürrem and İbrahim continue struggling against each other. Süleyman is getting suspicious about İbrahim.

Süleyman executes İbrahim and then sends the corpse to İbrahim's palace. Hatice becomes very sad about the death of her beloved and disowns her brother Süleyman. Together Hatice and Mahidevran plan on killing Hürrem by sending Diana, Mahidevran's servant, to murder Hürrem as a revenge, since they see Hürrem responsible for the execution of İbrahim. Şah Sultan decides to stand against Hürrem for her self-interests. Nasuh sends Esma, İbrahim's later daughter, to İbrahim's family as Nigar, her mother, is now married to Rüstem.

Diana didn't succeed in killing Hürrem and now Diana is serving Hürrem loyally. Şah makes Hürrem think that Mustafa is coming to usurp the throne from his father while Süleyman is on a campaign and that Süleyman and her sons are wounded and trapped. Hürrem decided to take her sons, Bayezid and Cihangir(whom stay in the Palace) away from Mustafa. But, Şah took Hürrem's sons to an old farm. Hürrem discovers this and get there personally to save her sons. But Şah was waiting for her there and told Hürrem that all of this was only a game. Hürrem decided to finish with Şah. Mihrimah is warned by her mother not to trust anyone except her.

Hatice wants to finish with Hürrem because she's seeing Şah doing nothing. Hatice sends someone to tell Hürrem that her daughter Mihrimah was in the Marble Palace but in reality, Mihrimah is still in the Palace. When Hürrem gets there, Hatice ordered a woman, who practiced black magic to put a hanker chief with witch craft in Hürrem's mouth. Hürrem is found unconscious by Sümbül, her most loyal servant, and she is taken back to the. After sometimes, Hürrem discovers that she's being witched and she warned Hatice of not playing with her. Şah gets angry of Hatice of doing things behind her back. Şah has another plan to get rid of Hürrem. Hürrem speaks with a priest and she recites theQuran to feel well. Süleyman gets another time to a campaign and Bayezid stays in the Palace. Angry, Bayezid escaped the Palace and goes in the campaign without anyone to know. But, Selim saw him and Bayezid returned to the Palace. Hürrem decided to rent money from Rakilah, a girl who rents money but, the money has been stolen by Şah. So, Hürrem was obliged to rent money from another one before the Harem's girls make problems. Rakilah took orders from Şah to say to Hürrem that Portia Hatun can perhaps help Hürrem. Portia is a Venetian woman and the Sultan was at war with Venice at that time. Hürrem took the money from Portia and then gives back the gold. The Sultan returned from the campaign and sets in Edirne. Şah took the papers of Hürrem and Portia's trait and gets to Edirne to explain everything to Süleyman. But, Hürrem sends guards to attack the cars of Şah. Şah gives them the fake papers and gives the real ones to Süleyman. Süleyman decides to exile Hürrem in Edirne and then he returns to Topkapı Palace. Şah orders Rüstem Pasha to kill Hürrem Sultan while she's in Edirne. But, he refused and decided to stay loyal to Hürrem. Rüstem decides that in marrying Mihrimah Sultan, his relation with Süleyman can get closer and he is going to enter the Diwan. Hürrem accepted but Mihrimah refused when she saw her mother in Edirne.

A Black Death epidemic breaks out and Ayas Mehmed Pasha and Mustafa Pasha die from the epidemic. Then, Lütfi Pasha becomes Grand Vizier and Şah is now more powerful. A doctor saves Hürrem by telling the Sultan that the illness comes to Edirne. Hürrem returns in Topkapı. Süleyman decided to marry Hatice to Hüsrev Pasha. She is obliged to accept but she continues living in her old Palace. When Süleyman gets to know this, he sends Hatice to the palace of Hüsrev. Mihrimah accepts to marry Rüstem. Mustafa falls in disgrace from his father because he's doing things without telling his father. Hürrem tells Mihirmah her decision of marrying Mihirmah with Rüstem and Mihirmah becomes upset. Hatice, Lütfi and Şah have a plan to get rid of Rüstem so he can not marry Mihrimah. Mahidevran suggests not to kill Rüstem but creating rumors that Rustem is very sick. Süleyman is sending a doctor to confirm Rüstems sickness. The doctor finds a louse on Rüstem's head and takes it to Istanbul as a sign that Rüstem is healthy. Rüstem is coming back to Istanbul to marry Mihrimah.

Mihrimah gives birth to a girl named Humaşah. Şah sends Mihrimah a girl to give milk to Humaşah. Lütfi proposes to Süleyman to send Mehmed, Selim and Beyazid as according to the traditions.

Nigar returns to Istanbul. She meets Şah and she wants to take revenge. Hatice and Şah accept. They help Nigar entering in the Palace of Rüstem and Mihrimah. At night Nigar should kill Rüstem and Hürrem . But, when she sees Mihrimah's daughter, she thinks about her own daughter and takes the child of Rüstem and Mihrimah away. Nigar passes baby back to Rüstem while a soldier aims to kill her on the order of Şah Sultan but she commits suicide and the soldier was not able to kill her.

Lütfi Pasha continues his crusade against prostitution. When one of the convicts makes fun of him he gets angry and punishes her without the permission of the judge. Şah discovers this and shouts at Lütfi. Lütfi beats and slaps Şah. Şah divorces from him, and he loses his position and is sent far away.

Mustafa meets the Austrian ambassador. This leads to a conflict between Süleyman and Mustafa. Süleyman punishes Mustafa by not allowing him to participate in the upcoming campaign. And after the campaign, Mustafa will not return to Manisa but to Amasya. This led to discussions between Mehmed and Mustafa.

A fake letter tells Hürrem that her son Selim is very sick. Hürrem is now going to Konya to see her son. But in reality, he is pretty well and now Hürrem is captured in a secret place. Mihrimah is accusing Şah, Hatice and Mahidevran for this. Süleyman gets very upset. Hatice commits suicide fearing from the sultan's decision after knowing that she was responsible for Hürrem's disparition. She died knowing that she took vengeance on her husband's death.

Süleyman decides to go for war against Charles V, and he achieves a victory, while on the other hands:

Malkoçoğlu Balı Bey finds a lead on Ali Ağa (who was Hatice's servant and is responsible for abducting Hürrem) and he went to follow this lead without informing Sultan Süleyman.Mihrimah discovers that her aunt Şah is having a spy in the Harem (her daughter's care taker) and confront her with the fact and threats her to inform her father (Süleyman) if she doesn't leave the city and gives away her money to Hürrem's charity institute.Süleyman's son, Mehmed, gets murdered by his closest Şahinbey (Ilyas who works for Mahidevran) by wounding him and transferring a contiguous disease to him. The news reaches Süleyman who falls in deep sorrows and feels that everything is falling apart.