Meryem Uzerli as Haseki Hurrem Sultan

Filing Ahmed as Nigar Kalfa

Burcu Tuna as Gülnihal Hatun

Sebhat Kumas as Esma Hatun

Engin Günaydin as Gül Aga

Selim Bayraktar as Sumbul Aga

Leyla Feray as Fatma Hatun

Hande Doğandemir as Zeynep Hatun

Yüksel Ünal as Seker Aga

Jonathan Rhys Meyers as King Henry VIII

Natalie Dormer as Lady Anne Boelyn

Maria Doyle Kennedy as Queen Catherine of Aragon

Henry Cavill as Charles Brandon, Duke of Suffolk

Callum Blue as Sir Anthony Knivert

Sam Neil as Cardinal Thomas Wosely

James Frain as Sir Thomas Cromwell

Nick Dunning as Lord Thomas Boleyn, Earl of Wiltshire